I know the difference between them, but is there any difference while reversing? Is it easier to reverse CISC than RISC?
It's usually easier to distinguish between data and code or detect pointers to code on RISC processor because RISC instruction has a fixed (or very much less variable) length as opposite to CISC. It means, for example, that RISC functions addresses are usually aligned to largest instruction size.
Based on comparison of architectures I worked with( Risc: (MIPS, PPC, ARM, aarch64), Cisc: (Intel)) I'd say that CISC itself is more complicated, which makes reversing of programs for it more complicated.