2 Paraphrased the title in a more specific way.
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write in binary Binary patching using radare2 in debug mode

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write in binary using radare2

Im a newbe in radare and while I tried to patch a crackme binary, I opened it the first time in debug mode (-d), while debugging I used oo+ to reopen it with write mode, when I modify an instruction using wx, it works but when I quit it gives me two confirmation messages with yes no I press enter two times, then it get back to the original stat, and loose the modification, How could I keep changes even after quitting ???